Diagnostically Challenging Multifocal Penile Epithelioid Hemangioma Successfully Treated With Doxorubicin Hydrochloride

Am J Dermatopathol. 2024 Apr 1;46(4):228-231. doi: 10.1097/DAD.0000000000002642. Epub 2024 Mar 8.


Epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is an unusual vascular proliferation that tends to manifest in the head and neck region. Its occurrence on the penis is rare, with only scarce reported cases in the literature. The histopathological examination of this condition poses a challenge because it shares similarities with other entities, such as epithelioid hemangioendothelioma, epithelioid angiosarcoma, cutaneous epithelioid angiomatous nodule, or Kaposi sarcoma (KS). The infrequency of EH in penile locations underscores the need for accurate diagnostic differentiation and tailored treatment strategies for this atypical presentation. This case report highlights a rare instance of multifocal penile EH. The patient's lesions exhibited distinctive histopathologic features, with extensive eosinophilic infiltration, presence of necrosis, and infiltration to subcutaneous fat. The patient was treated with doxorubicin, a chemotherapy drug, with a very good response. This successful therapeutic outcome underscores the potential efficacy of doxorubicin in the management of multifocal penile EH. The comprehensive analysis of this case contributes to our understanding of the clinical presentation, histopathologic features, and treatment modalities for this rare penile tumor, providing valuable insights for future clinical considerations.

Publication types

  • Case Reports

MeSH terms

  • Angiolymphoid Hyperplasia with Eosinophilia* / pathology
  • Diagnosis, Differential
  • Doxorubicin / therapeutic use
  • Hemangioendothelioma, Epithelioid* / drug therapy
  • Hemangioendothelioma, Epithelioid* / pathology
  • Hemangioma* / pathology
  • Humans
  • Male
  • Penile Neoplasms* / diagnosis
  • Penile Neoplasms* / drug therapy
  • Penis / pathology


  • Doxorubicin