Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): resistance to Meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes

Cancer Immunol Immunother. 1985;19(2):73-8. doi: 10.1007/BF00199712.


When a hot water extract of Chlorella vulgaris (CE) was injected into the peritoneal cavity of BALB/c mice inoculated with syngeneic Meth-A tumor cells, the survival times were strikingly prolonged. Furthermore, peritoneal exudate cells (PEC) rich in polymorphonuclear cells (PMN) obtained from normal mice 24 h after CE injection exhibited an antitumor effect in a Winn-type assay using normal recipients. Such an activity of PEC remained almost intact after T cell or macrophage depletion. However, such PEC did not express an antitumor effect in a Winn-type assay using irradiated recipients. It was suggested that CE-induced PEC, presumably PMN, expressed an antitumor effect in cooperation with a host- or recipient-derived element(s) sensitive to irradiation. The antitumor mechanism of CE may be different from that of OK-432, one of the biological response modifiers.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / immunology*
  • Ascites / therapy
  • Chlorella / physiology*
  • Female
  • Fibrosarcoma / therapy*
  • Immunity, Cellular / radiation effects
  • Immunotherapy
  • Macrophages / immunology
  • Mice
  • Mice, Inbred BALB C
  • Neutrophils / immunology
  • Plant Extracts / immunology
  • Plant Extracts / therapeutic use*


  • Antineoplastic Agents, Phytogenic
  • Plant Extracts