A 15% Trichloroacetic Acid + 3% Glycolic Acid Chemical Peel Series Improves Appearance of Hand Lentigines: An Evaluator-Blinded, Split-Hand Prospective Trial

Dermatol Surg. 2024 May 1;50(5):467-470. doi: 10.1097/DSS.0000000000004114. Epub 2024 Mar 8.


Background: Improving the appearance of lentigines on the hands is a key component to hand rejuvenation. Soft tissue fillers revolumize hands, but do not address pigmentary changes. OBJECTIVE: This study investigated the effiacy of a 15% trichloroacetic acid (TCA) + 3% glycolic acid (GA) combination peel in improvement of appearance of hand lentigines.

Methods: A prospective evaluator-blinded, split-hand study was performed using a 15% TCA + 3% GA peel to treat patients with hand lentigines. Subjects received a total of 3 treatments at 4-week intervals on 1 hand, with the other hand serving as an untreated control. Final photographs were taken 12 weeks after the last treatment. Two blinded board-certified dermatologists graded improvement in hand lentigines using a 5-point scale.

Results: Eighteen of 20 patients completed the study (90%). The mean age was 64.4 years (SE 1.6, range 51-71). The mean pain scores were 3.8 (SE 0.4) on a 10-point scale (1 = no pain, 10 = extremely painful). Blinded evaluators correctly identified the after-treatment photographs in 16 patients (88%). Physician and patient-graded mean improvement of lentigines was significant for treated versus control hands ( p < .01). No adverse events were noted.

Conclusion: A series of three 15% TCA + 3% GA peels are effective and safe in the treatment of hand lentigines.

Trial registration: ClinicalTrials.gov NCT05471947.

MeSH terms

  • Aged
  • Chemexfoliation* / methods
  • Female
  • Glycolates* / administration & dosage
  • Hand
  • Humans
  • Keratolytic Agents / administration & dosage
  • Lentigo / drug therapy
  • Male
  • Middle Aged
  • Prospective Studies
  • Single-Blind Method
  • Treatment Outcome
  • Trichloroacetic Acid* / administration & dosage
  • Trichloroacetic Acid* / adverse effects


  • Trichloroacetic Acid
  • Glycolates
  • glycolic acid
  • Keratolytic Agents

Associated data

  • ClinicalTrials.gov/NCT05471947