Novel histone post-translational modifications in Alzheimer's disease: current advances and implications

Clin Epigenetics. 2024 Mar 9;16(1):39. doi: 10.1186/s13148-024-01650-w.


Alzheimer's disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it. With the development of mass spectrometry and proteomics, an increasing number of novel HPTMs, including lactoylation, crotonylation, β-hydroxybutyrylation, 2-hydroxyisobutyrylation, succinylation, and malonylation, have been identified. These novel HPTMs closely link substance metabolism to gene regulation, and an increasing number of relevant studies on the relationship between novel HPTMs and AD have become available. This review summarizes the current advances and implications of novel HPTMs in AD, providing insight into the deeper pathogenesis of AD and the development of novel drugs.

Keywords: Alzheimer’s disease; Histone; Novel histone post-translational modifications.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Alzheimer Disease* / genetics
  • DNA Methylation
  • Histones* / metabolism
  • Humans
  • Protein Processing, Post-Translational


  • Histones