Advances in photodynamic therapy of pathologic scar

Photodiagnosis Photodyn Ther. 2024 Apr:46:104040. doi: 10.1016/j.pdpdt.2024.104040. Epub 2024 Mar 8.

Abstract

Pathologic scars include keloids and hypertrophic scars due to abnormal wound healing. Both cause symptoms of itching and pain; they also affect one's appearance and may even constrain movement. Such scars place a heavy burden on the individual's physical and mental health; moreover, treatment with surgery alone is highly likely to leave more scarring. Therefore, there is an urgent need for a treatment that is both minimally invasive and convenient. Photodynamic therapy (PDT) is an emerging safe and noninvasive technology wherein photosensitizers and specific light sources are used to treat malignant tumors and skin diseases. Research on PDT from both the laboratory and clinic has been reported. These findings on the treatment of pathologic scars using photosensitizers, light sources, and other mechanisms are reviewed in the present article.

Keywords: Hypertrophic scar; Keloid; Pathologic scar; Photodynamic therapy; Photosensitizers.

Publication types

  • Review

MeSH terms

  • Cicatrix / drug therapy
  • Cicatrix, Hypertrophic / drug therapy
  • Humans
  • Keloid / drug therapy
  • Photochemotherapy* / methods
  • Photosensitizing Agents* / therapeutic use

Substances

  • Photosensitizing Agents