Genetic variation drives differences in obesity-related gene regulation

Abstract

Heikkinen and colleagues recently demonstrated that genetic variation, rather than dietary changes, governs gene regulation in liver. This finding highlights the impact of noncoding variants on chromatin accessibility, histone modifications, transcription factor binding, and gene expression and has implications for future research directions in understanding the genetic basis of disease.

Keywords: GWAS; chromatin; epigenome; gene regulation; genetic variation; genetics.