Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis

Abhishek Gami; John Woller; Paul Scheel; Syed Abbas Ali; Carol Ann Huff; Charles Steenbergen Jr; Marc Halushka; Kavita Sharma; Michael Polydefkis; Joban Vaishnav

doi:10.1016/j.jaccas.2024.102285

Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis

JACC Case Rep. 2024 Mar 5;29(7):102285. doi: 10.1016/j.jaccas.2024.102285. eCollection 2024 Apr 3.

Authors

Affiliations

¹ Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Department of Cardiovascular Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁵ Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
⁶ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and ATTR cardiac amyloidosis and demonstrate the importance of clinical history and endomyocardial biopsy in diagnosis of this rare entity.

Keywords: cardiac amyloidosis; endomyocardial biopsy; light chain; transthyretin.

Publication types

Case Reports