Carbazole and Quinazolinone Derivatives from a Fluoride-Tolerant Streptomyces Strain OUCMDZ-5511

J Agric Food Chem. 2024 Mar 27;72(12):6424-6431. doi: 10.1021/acs.jafc.4c00780. Epub 2024 Mar 12.

Abstract

Six new 9H-carbazole derivatives (1-6) and nine previously reported compounds (7-15) were isolated from a fermented solid medium of the Thailand mangrove-derived Streptomyces strain, OUCMDZ-5511, under fluoride stress. Compounds 2-5, 12, and 15 were exclusively present in the fluoride-supplemented fermentation medium, while compounds 7-9, 13, and 14 were newly discovered natural products. The molecular structures of the compounds were identified by a spectroscopic analysis. The new compound 2 displayed antiquorum sensing activity against Chromobacterium violaceum ATCC 12472 by reducing the violacein production and inhibiting the biofilm formation in a concentration-dependent manner. The study revealed that compound 2 could be a novel potential inhibitor of quorum sensing.

Keywords: 9H-carbazole; Streptomyces; antiquorum sensing; fluoride tolerance.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Biofilms
  • Carbazoles / pharmacology
  • Fluorides* / pharmacology
  • Quorum Sensing
  • Streptomyces*

Substances

  • carbazole
  • Fluorides
  • Anti-Bacterial Agents
  • Carbazoles