Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice

Nathan H Witmer; Connor R Linzer; Ryan L Boudreau

doi:10.1016/j.cmet.2024.02.008

Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice

Cell Metab. 2024 May 7;36(5):879-881. doi: 10.1016/j.cmet.2024.02.008. Epub 2024 Mar 11.

Authors

Nathan H Witmer¹, Connor R Linzer², Ryan L Boudreau³

Affiliations

¹ Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Molecular Medicine Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
² Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
³ Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Molecular Medicine Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center and Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: ryan-boudreau@uiowa.edu.

Abstract

Witmer et al. provide genomic and molecular evidence to demonstrate that Fndc5 (irisin myokine precursor protein) is translated in humans from an overlooked upstream ATG codon.

Publication types

Research Support, Non-U.S. Gov't
Letter

MeSH terms

Animals
Codon, Initiator* / genetics
Fibronectins* / genetics
Fibronectins* / metabolism
Humans
Mice
Myokines
Protein Biosynthesis

Substances

Fibronectins
FNDC5 protein, human
Codon, Initiator
FNDC5 protein, mouse
Myokines

Abstract

Publication types

MeSH terms

Substances

Grants and funding