Targeting gut microbiota to counteract acetaminophen-induced acute liver injury

Peng Chen

doi:10.1016/j.tim.2024.02.011

Targeting gut microbiota to counteract acetaminophen-induced acute liver injury

Trends Microbiol. 2024 May;32(5):419-421. doi: 10.1016/j.tim.2024.02.011. Epub 2024 Mar 11.

Author

Peng Chen¹

Affiliation

¹ Department of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: perchen@smu.edu.cn.

PMID: 38472076
DOI: 10.1016/j.tim.2024.02.011

Abstract

Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose-induced acute liver injury (AILI) is a huge threat to public health worldwide. Recent research clearly shows that the intestinal microbiota (IM) is a key modulator in AILI. Herein, I discuss the latest findings on how the IM regulates AILI and the potential interventions to combat AILI by targeting the IM.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acetaminophen* / adverse effects
Animals
Chemical and Drug Induced Liver Injury* / microbiology
Chemical and Drug Induced Liver Injury* / prevention & control
Gastrointestinal Microbiome* / drug effects
Humans
Liver / drug effects
Liver / microbiology

Substances

Acetaminophen