Hats off to 20S proteasome substrate discovery

Mol Syst Biol. 2024 Apr;20(4):293-295. doi: 10.1038/s44320-024-00028-7. Epub 2024 Mar 12.


Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.

MeSH terms

  • Cytoplasm
  • Proteasome Endopeptidase Complex*


  • Proteasome Endopeptidase Complex