Assisted reproductive technologies could be associated with higher risk of parenting difficulties in women with postpartum major depression

Florence Gressier; Antonia Mezzacappa; Nine Glangeaud-Freudenthal; Bruno Falissard; Emmanuelle Corruble; Anne-Laure Sutter-Dallay

doi:10.1007/s00737-024-01454-0

Assisted reproductive technologies could be associated with higher risk of parenting difficulties in women with postpartum major depression

Arch Womens Ment Health. 2024 Mar 13. doi: 10.1007/s00737-024-01454-0. Online ahead of print.

Authors

Florence Gressier¹, Antonia Mezzacappa², Nine Glangeaud-Freudenthal³, Bruno Falissard⁴, Emmanuelle Corruble², Anne-Laure Sutter-Dallay⁵

Affiliations

¹ Department of Psychiatry, Faculté de Médecine Paris-Saclay, MOODS Team, CESP, Inserm U1018, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Saclay, Université Paris-Saclay, 78 rue du General Leclerc, 94 275 Le Kremlin Bicêtre, Paris, France. florence.gressier@aphp.fr.
² Department of Psychiatry, Faculté de Médecine Paris-Saclay, MOODS Team, CESP, Inserm U1018, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Saclay, Université Paris-Saclay, 78 rue du General Leclerc, 94 275 Le Kremlin Bicêtre, Paris, France.
³ Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics (U1153), INSERM Obstetrical, Paris Descartes University, Paris, France.
⁴ Department of Biostatistics, Maison de Solenn, Université Paris Saclay, UVSQ, CESP, Inserm U1018, Paris, France.
⁵ University Department of Child and Adolescent Psychiatry, Charles-Perrens Hospital, Bordeaux, France, INSERM, Bordeaux Population Health Research Center, U1219, Bordeaux University, Bordeaux, France.

PMID: 38478036
DOI: 10.1007/s00737-024-01454-0

Abstract

No increased risk of postpartum major depression (PPMD) was reported in women conceiving through assisted reproductive technologies (ART). However, ART may be associated with a higher risk of parenting difficulties in women with PPMD. In 359 women with a PPMD admitted to a Mother-Baby Unit (MBU), ART-women (4.2%) showed a 5-fold higher rate of parenting difficulties than those with spontaneous pregnancy (73.33% vs. 35.17%, multivariate ORa = 5.09 [1.48-17.48] p = 0.01). Specific support for mother-child relationship should be implemented in ART-women with PPMD.

Keywords: Depression; Parenting; Postpartum; Reproductive techniques, assisted.