Predicting plasma cell retention and loss over a lifetime

Marcus J Robinson; David M Tarlinton

doi:10.1016/j.immuni.2024.02.012

Predicting plasma cell retention and loss over a lifetime

Immunity. 2024 Mar 12;57(3):408-410. doi: 10.1016/j.immuni.2024.02.012.

Authors

Marcus J Robinson¹, David M Tarlinton²

Affiliations

¹ Department of Immunology, Monash University, Level 6 Burnet Tower, 89 Commercial Road, Prahran, VIC 3004, Australia.
² Department of Immunology, Monash University, Level 6 Burnet Tower, 89 Commercial Road, Prahran, VIC 3004, Australia. Electronic address: david.tarlinton@monash.edu.

PMID: 38479357
DOI: 10.1016/j.immuni.2024.02.012

Abstract

Plasma cells (PCs) rely on external survival cues for persistence, which limits the size of the PC pool. How, then, are new specificities incorporated into a saturated system? In this issue of Immunity, Simons and Karin put forward a mathematical framework to explain PC retention that makes testable predictions about steady-state lifespan structure, withstands tests based on accrual and displaceability, and accounts for lifespan stratification with specificity.

MeSH terms

Plasma Cells*