Abstract
We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, and MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with immunohistochemistry from tissue blocks. Of 83 patients, PD-L1 expression was observed in 18.1% (n = 15) of the patients. None of the patients exhibited LAG-3 expression. TIM-3 expression was 4.9% (n = 4), OX40L was 22.9% (n = 19), and 8.4% (n = 7) of the patients had MSI tumor. A low-to-intermediate positive correlation was observed between PD-L1 and TIM-3 expressions (rho: 0.333, p < 0.01). Although PD-L1 expression was higher in grade 3 NET/NEC, MSI status was prominent in grade 1/2 NET.
Keywords:
LAG-3; MSI; OX40L; PD-L1; TIM-3.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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B7-H1 Antigen* / analysis
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B7-H1 Antigen* / metabolism
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DNA Repair
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Female
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Gastrointestinal Neoplasms* / chemistry
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Gastrointestinal Neoplasms* / pathology
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Hepatitis A Virus Cellular Receptor 2* / analysis
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Hepatitis A Virus Cellular Receptor 2* / metabolism
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Humans
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Immune Checkpoint Proteins* / analysis
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Immune Checkpoint Proteins* / metabolism
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Immunohistochemistry
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Lymphocyte Activation Gene 3 Protein / analysis
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Lymphocyte Activation Gene 3 Protein / metabolism
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Male
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Middle Aged
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Neoplasm Grading
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Neuroendocrine Tumors* / chemistry
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Neuroendocrine Tumors* / pathology
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OX40 Ligand / analysis
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OX40 Ligand / metabolism
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Pancreatic Neoplasms* / chemistry
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Pancreatic Neoplasms* / pathology
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Retrospective Studies
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Young Adult
Substances
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B7-H1 Antigen
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HAVCR2 protein, human
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Hepatitis A Virus Cellular Receptor 2
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Immune Checkpoint Proteins
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Lymphocyte Activation Gene 3 Protein
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OX40 Ligand