Deep Vein Thrombosis as the Presenting Sign in an Adolescent With New-Onset Type 2 Diabetes

Felicia Cooper; Mauri Carakushansky; Craig M Johnson; Shilpa Gurnurkar

doi:10.1210/jcemcr/luae038

Deep Vein Thrombosis as the Presenting Sign in an Adolescent With New-Onset Type 2 Diabetes

JCEM Case Rep. 2024 Mar 15;2(3):luae038. doi: 10.1210/jcemcr/luae038. eCollection 2024 Mar.

Authors

Felicia Cooper¹, Mauri Carakushansky¹, Craig M Johnson², Shilpa Gurnurkar¹

Affiliations

¹ Department of Endocrinology, Nemours Children's Health Florida, Orlando, FL 32827, USA.
² Department of Interventional Radiology, Nemours Children's Health Florida, Orlando, FL 32827, USA.

Abstract

Prothrombin G20210A mutation occurs in only 2% to 3% of the population, but usually does not become apparent unless the individual exhibits another risk factor for clotting. A risk factor such as hyperglycemia in the setting of diabetes mellitus may accelerate this clotting process, even at a very young age. In this case report, we discuss a 15-year-old boy presenting with left calf swelling and pain, found to have extensive deep vein thrombosis in the setting of hyperglycemia and a newly discovered prothrombin G20210A mutation. Venous thromboembolism in the setting of type 2 diabetes mellitus has not been described in children.

Keywords: deep vein thrombosis; diabetes; pediatric; prothrombin mutation.

Publication types

Case Reports