Tumor-Induced Parkinsonism Due to a Large Meningioma Diagnosed by 99m Tc-TRODAT-1 SPECT/CT

Clin Nucl Med. 2024 Jun 1;49(6):e284-e285. doi: 10.1097/RLU.0000000000005178. Epub 2024 Mar 18.


A 67-year-old woman complained of rest and postural tremors in her left upper extremity, associated with bradykinesia and gait disorder since 2 years ago, with no significant response to antiparkinsonism drugs. Dopamine transporter SPECT/CT revealed a remarkable area of 99m Tc-TRODAT-1 uptake in a huge tumoral lesion in the right frontotemporal region, compressing and dislocating the right striatum with evidence of significant midline shift. The patient underwent surgical resection with a diagnosis of meningioma on preoperative MRI and postoperative histology report, experiencing a marked recovery in symptoms after 1 month.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Humans
  • Meningeal Neoplasms / complications
  • Meningeal Neoplasms / diagnostic imaging
  • Meningioma* / complications
  • Meningioma* / diagnostic imaging
  • Organotechnetium Compounds*
  • Parkinsonian Disorders* / diagnostic imaging
  • Single Photon Emission Computed Tomography Computed Tomography*
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes*


  • technetium Tc 99m TRODAT-1
  • Tropanes
  • Organotechnetium Compounds