Differential contributions of the hippocampal dentate gyrus and CA1 subfield to mnemonic discrimination

Hippocampus. 2024 Jun;34(6):278-283. doi: 10.1002/hipo.23604. Epub 2024 Mar 19.

Abstract

Evidence suggests that individual hippocampal subfields are preferentially involved in various memory-related processes. Here, we demonstrated dissociations in these memory processes in two unique individuals with near-selective bilateral damage within the hippocampus, affecting the dentate gyrus (DG) in case BL and the cornu ammonis 1 (CA1) subfield in case BR. BL was impaired in discriminating highly similar objects in memory (i.e., mnemonic discrimination) but exhibited preserved overall recognition of studied objects, regardless of similarity. Conversely, BR demonstrated impaired general recognition. These results provide evidence for the DG in discrimination processes, likely related to underlying pattern separation computations, and the CA1 in retention/retrieval.

Keywords: case study; hippocampus; memory; mnemonic similarities task; pattern separation.

MeSH terms

  • Aged
  • CA1 Region, Hippocampal* / physiology
  • Dentate Gyrus* / physiology
  • Discrimination, Psychological* / physiology
  • Female
  • Humans
  • Male
  • Memory / physiology
  • Middle Aged
  • Recognition, Psychology / physiology