Sequelae Treatment Needs Following Peripheral Facial Palsy: Retrospective Analysis of 525 Patients

Otol Neurotol. 2024 Jun 1;45(5):e450-e456. doi: 10.1097/MAO.0000000000004162. Epub 2024 Mar 21.

Abstract

Objective: This study uses retrospective longitudinal data from a large unselected cohort of patients with peripheral facial paralysis to determine the prevalence and patient characteristic predictors of sequelae receiving intervention.

Study design: Retrospective case review.

Setting: Karolinska University Hospital in Stockholm Sweden serves as the only tertiary facial palsy center in the region. Here, patients are diagnosed, are followed up, and undergo all major interventions.

Patients: All adult patients presenting with peripheral facial palsy due to idiopathic, zoster, or Borrelia origin at Karolinska, January 1, 2010 to December 31, 2011 with follow-up until December 2022.

Interventions: Patient charts were studied to identify patient characteristics, etiology, initial treatment, severity of palsy, and treatments targeting sequelae.

Main outcome measures: Types of initial and late treatments were noted. Sunnybrook and/or House-Brackmann scales were used for palsy grading.

Results: Five hundred twenty-five patients were included. Thirty-three patients (6.3%) received botulinum toxin injections and/or surgical treatment. In this subgroup, 67% received corticosteroids compared to 85% of all patients ( p = 0.005), cardiovascular disease prevalence was higher (23 and 42%, respectively, p = 0.009). For 81 patients (15%), follow-up was discontinued although the last measurement was Sunnybrook less than 70 or House-Brackmann 3 to 6.

Conclusions: Of patients with peripheral facial palsy, 6.3% underwent injections and/or surgical treatment within 12 years. However, due to a rather large proportion not presenting for follow-up, this might be an underestimation. Patients receiving late injections and/or surgical treatment had more comorbidities and received corticosteroid treatment to a significantly lower extent in the acute phase of disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Botulinum Toxins / therapeutic use
  • Facial Paralysis* / epidemiology
  • Female
  • Herpes Zoster Oticus / complications
  • Herpes Zoster Oticus / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sweden / epidemiology

Substances

  • Botulinum Toxins