L-arginine supplementation protects against thrombosis and renal dysfunction in mice treated with the cyclooxygenase-2 inhibitor parecoxib

J Thromb Haemost. 2024 Jun;22(6):1798-1801. doi: 10.1016/j.jtha.2024.03.006. Epub 2024 Mar 20.

Authors

Ricky Vaja¹, Maria Lopes-Pires¹, Fisnik Shala¹, Neringa Cypaite¹, Maria Vinokurova¹, Plinio Ferreira¹, Jane A Mitchell², Nicholas S Kirkby³

Affiliations

¹ National Heart & Lung Institute, Imperial College London, London, United Kingdom.
² National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address: j.a.mitchell@ic.ac.uk.
³ National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address: n.kirkby@imperial.ac.uk.

PMID: 38518895
DOI: 10.1016/j.jtha.2024.03.006

No abstract available

Publication types

Letter

MeSH terms

Animals
Arginine*
Cyclooxygenase 2 / metabolism
Cyclooxygenase 2 Inhibitors* / pharmacology
Cyclooxygenase 2 Inhibitors* / therapeutic use
Dietary Supplements
Disease Models, Animal
Isoxazoles* / therapeutic use
Kidney / drug effects
Kidney / physiopathology
Kidney Diseases / chemically induced
Kidney Diseases / prevention & control
Male
Mice
Mice, Inbred C57BL
Thrombosis / drug therapy
Thrombosis / prevention & control

Substances

Cyclooxygenase 2 Inhibitors
parecoxib
Isoxazoles
Arginine
Cyclooxygenase 2