Balancing neuronal activity to fight neurodevelopmental disorders

Trends Neurosci. 2024 Apr;47(4):241-242. doi: 10.1016/j.tins.2024.03.002. Epub 2024 Mar 22.


In a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.

Keywords: PACS1; brain organoids; electrophysiology; neurodevelopment; neurons; pluripotent stem cells.

MeSH terms

  • Brain
  • Child
  • Humans
  • Induced Pluripotent Stem Cells* / physiology
  • Neural Stem Cells*
  • Neurodevelopmental Disorders*
  • Neurons
  • Vesicular Transport Proteins


  • PACS1 protein, human
  • Vesicular Transport Proteins