Balancing neuronal activity to fight neurodevelopmental disorders

Abstract

In a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.

Keywords: PACS1; brain organoids; electrophysiology; neurodevelopment; neurons; pluripotent stem cells.