Comparison of the Efficacy of Oral Magnesium with Oral Ketorolac for Postoperative Pain Management in Anorectal Surgery: A Double-blinded Randomized Clinical Trial

Seyed Jalal Eshagh Hoseini; Farzanesadat Ghazi; Mohsen Eshraghi; Mostafa Vahedian; Mohammad Reza Pashaei; Mohamad Amin Habibi; Sajjad Ahmadpour

doi:10.2174/0115748871290318240218195517

Comparison of the Efficacy of Oral Magnesium with Oral Ketorolac for Postoperative Pain Management in Anorectal Surgery: A Double-blinded Randomized Clinical Trial

Rev Recent Clin Trials. 2024 Mar 21. doi: 10.2174/0115748871290318240218195517. Online ahead of print.

Authors

Seyed Jalal Eshagh Hoseini¹, Farzanesadat Ghazi², Mohsen Eshraghi³, Mostafa Vahedian⁴, Mohammad Reza Pashaei^{5

6}, Mohamad Amin Habibi⁷, Sajjad Ahmadpour⁶

Affiliations

¹ Department of Surgery, School of Medicine, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran.
² Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
³ Department of Surgery, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
⁴ Department of Family and Community Medicine, School of Medicine, Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran.
⁵ Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
⁶ Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
⁷ Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran.

PMID: 38523517
DOI: 10.2174/0115748871290318240218195517

Abstract

Background: Due to the presence of postoperative pain in patients undergoing anorectal surgery, and since the pain affects the quality of life of patients, we aimed to compare the analgesic effectiveness of oral magnesium with oral ketorolac to choose the right analgesic drug for these patients.

Methods: This study was a double-blind, randomized clinical trial performed on 104 candidates undergoing anorectal surgery. Patients were randomly divided into two groups. Group 1 received oral magnesium (250 mg daily), and group 2 received oral ketorolac (10 mg daily). The medicine was given to the patient 2 hours after the operation and every 12 hours for 10 days. Pain measurements were recorded at 24-hour intervals after surgery based on the visual analog scale and numerical rating scale.

Results: This study found that postoperative pain was reduced in patients taking magnesium tablets, similar to the ketorolac group. A similar decreasing trend was observed in the group receiving ketorolac; however, the reduction was more pronounced in the magnesium group and was statistically significant on days 1, 3, and 5 (p < 0.001). However, insignificant differences were noted between the two groups on the seventh (p = 0.093) and tenth (p = 0.088) postoperative days.

Conclusion: Taking magnesium tablets after surgery has a suitable analgesic effect, which is similar to oral ketorolac tablets from the fifth day onwards, but in the initial days, it is less effective than ketorolac statistically.

Keywords: Anorectal surgery; analgesia; ketorolac; magnesium.; postoperative pain.

Publication types

Clinical Trial