Association between glycemic control and patient-reported outcomes in adults with type 1 diabetes in Japan: the SAGE study subanalysis

Rimei Nishimura; Akira Shimada; Norio Abiru; Munehide Matsuhisa; Yoko Takahashi; Hiroshi Ikegami

doi:10.1007/s13340-023-00668-4

Association between glycemic control and patient-reported outcomes in adults with type 1 diabetes in Japan: the SAGE study subanalysis

Diabetol Int. 2023 Nov 22;15(2):212-222. doi: 10.1007/s13340-023-00668-4. eCollection 2024 Apr.

Authors

Rimei Nishimura¹, Akira Shimada², Norio Abiru^{3

4}, Munehide Matsuhisa⁵, Yoko Takahashi⁶, Hiroshi Ikegami⁷

Affiliations

¹ Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
² Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama, Japan.
³ Department of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
⁴ Midori Clinic, Nagasaki, Japan.
⁵ Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
⁶ General Medicine Medical, Sanofi K.K., Tokyo, Japan.
⁷ Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan.

Abstract

Aims/introduction: Psychosocial aspects and the quality of life (QOL) of individuals with diabetes are important for achieving glycemic control and treatment goals. Here, we describe patient-reported outcomes (PROs) of Japanese adults with type 1 diabetes (T1D) and evaluate the association thereof with glycemic control.

Materials and methods: This subanalysis of a subgroup of 528 Japanese participants in the SAGE study of adults with T1D used data on glycosylated hemoglobin (HbA1c) and PRO scores [Hypoglycemia Fear Survey-II (HFS-II), Problem Areas In Diabetes (PAID), Insulin Treatment Satisfaction Questionnaire (ITSQ), and Audit of Diabetes-Dependent QOL (ADDQoL)] and summarized the score by the predefined age groups (26-44-years: n = 208, 45-64-years: n = 217, and ≥ 65-years: n = 103). The association between PROs, achieving HbA1c < 7.0%, and individualized targets was explored using multivariate logistic regression analysis.

Results: The HFS-II and PAID scores were lower, and the ITSQ score was higher in the ≥ 65-years group than in the younger groups with a linear trend of better scores with increasing age (P for trend < 0.05). ADDQoL scores were similar across the age groups, and present QOL (ADDQoL subscale) tended to improve with age (P for trend < 0.05). Achieving HbA1c < 7.0% and individualized targets were associated with satisfaction with insulin treatment regarding glycemic control.

Conclusion: In Japanese adults with T1D, the impact on psychosocial aspects and QOL varied across age groups, with a trend of improving scores with age, potentially in relation to the less stringent glycemic control targets adopted in older individuals. Glycemic control was significantly associated with treatment satisfaction.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00668-4.

Keywords: Adults; Glycemic control; Japan; Patient-reported outcome; Type 1 diabetes.

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