Glycosylated RNA molecules (glycoRNAs) that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent paper (PMID 38262409) demonstrates that at least one function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycoRNAs bind to P-selectin, but not E-selectin.
© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.