Management of corneal melting after collagen cross-linking for keratoconus: a case report and a review of the literature

BMC Ophthalmol. 2024 Mar 25;24(1):131. doi: 10.1186/s12886-024-03400-1.

Abstract

Purpose: We describe the management of a case of severe corneal melting after corneal cross-linking (CXL) treated with a staged approach using a conjunctival flap followed by deep anterior lamellar keratoplasty (DALK).

Methods: A 12-year-old male developed severe corneal melting with pending perforation after an accelerated epithelium-off CXL protocol. We initially treated the patient with a conjunctival flap to prevent perforation. Three months later, we performed DALK to restore vision.

Results: Conjunctival flap surgery allowed us to avoid corneal perforation and penetrating keratoplasty (PK) à chaud. Once the inflammation had resolved, we recessed the conjunctiva and performed DALK for optical purposes. Twelve months later, the graft was clear and the corrected visual acuity was 20/25 (Snellen). No complications occurred after surgery.

Conclusions: Although CXL is considered a safe procedure, in rare cases it can lead to serious complications, such as corneal haze, infectious and non-infectious keratitis, stromal melting and perforation. Corneal melting and perforation are usually managed by emergency PK. Herein we suggest a staged approach involving an emergency conjunctival flap followed by DALK at a later time that allowed us to avoid PK à chaud.

Keywords: Collogen cross-linking; Corneal melting; Keratoconus; Lamellar keratoplasty.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Child
  • Collagen
  • Corneal Transplantation* / methods
  • Corneal Ulcer* / surgery
  • Humans
  • Keratoconus* / drug therapy
  • Keratoconus* / surgery
  • Keratoplasty, Penetrating / methods
  • Male
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Collagen