An Unusual Case of Serologically Confirmed Post-Partum Lyme Disease Following an Asymptomatic Borrelia burgdorferi Infection Acquired during Pregnancy and Lacking Vertical Transmission in Utero

Pathogens. 2024 Feb 20;13(3):186. doi: 10.3390/pathogens13030186.

Abstract

In this report, we describe a 23-year-old female who, while pregnant, was exposed to Borrelia burgdorferi but did not develop significant signs or symptoms (joint pain, arthritis) of Lyme disease until shortly after delivering a healthy child at term. Serologic testing confirmed infection with B. burgdorferi. A 3-week course of treatment with doxycycline was completely curative. There was no evidence for congenital or perinatal transmission of this pathogen at any point pre-term or postnatally. The key reasons that could account for this unique clinical scenario are discussed in the context of previously published related reports.

Keywords: Borrelia burgdorferi; Lyme disease; Western blot; arthritis; congenital transmission; pregnancy.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents* / therapeutic use
  • Antibodies, Bacterial / blood
  • Borrelia burgdorferi* / immunology
  • Borrelia burgdorferi* / isolation & purification
  • Doxycycline* / therapeutic use
  • Female
  • Humans
  • Infectious Disease Transmission, Vertical*
  • Lyme Disease* / diagnosis
  • Lyme Disease* / drug therapy
  • Lyme Disease* / transmission
  • Postpartum Period
  • Pregnancy
  • Pregnancy Complications, Infectious* / microbiology
  • Young Adult

Substances

  • Doxycycline
  • Anti-Bacterial Agents
  • Antibodies, Bacterial