Antimicrobial effects of cannabidiol on select agriculturally important Clostridia

Anaerobe. 2024 Jun:87:102843. doi: 10.1016/j.anaerobe.2024.102843. Epub 2024 Mar 25.


Amino acid-fermenting Clostridia have undesirable effects in agricultural systems, which can be mitigated by antibiotics, but resistance necessitates alternatives. Here, we demonstrate the efficacy of cannabidiol on growth and ammonia inhibition of five agriculturally relevant Clostridia: Clostridium sporogenes, Peptostreptococcus spp., Clostridioides difficile, Acetoanaerobium sticklandii, and Clostridium aminophilum.

Keywords: Antibiotic alternative; Antimicrobial activity; Cannabidiol; Clostridioides difficile; Clostridium sporogenes; Hyper-ammonia producing bacteria.

MeSH terms

  • Ammonia / metabolism
  • Anti-Bacterial Agents* / pharmacology
  • Cannabidiol* / pharmacology
  • Clostridium* / drug effects
  • Clostridium* / growth & development


  • Cannabidiol
  • Anti-Bacterial Agents
  • Ammonia