Early functional and morphologic vascular renal consequences of the diabetic state

Diabetologia. 1979 Aug;17(2):71-6. doi: 10.1007/BF01222205.


Renal hyperfunction and hypertrophy are characteristic findings in the early diabetic state, both in diabetes mellitus and in experimental diabetes. A number of structure-function relationships and their likely mechanisms are discussed. The metabolically induced hypertrophy of glomerular capillaries possibly plays a central role. Its cause is not known, but recent results on its time-course emphasize the probable long-term consequences of the irreversibility of the accumulation of basement membrane material.

Publication types

  • Review

MeSH terms

  • Albuminuria
  • Diabetes Mellitus / physiopathology
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetic Angiopathies / physiopathology*
  • Diabetic Nephropathies / physiopathology*
  • Glomerular Filtration Rate
  • Glucagon
  • Humans
  • Insulin
  • Kidney / physiopathology


  • Insulin
  • Glucagon