TRPV Channels in Osteoarthritis: A Comprehensive Review

Biomolecules. 2024 Feb 29;14(3):292. doi: 10.3390/biom14030292.

Abstract

Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete. In recent years, transient receptor potential vanilloid (TRPV) channels have emerged as key players in OA pathogenesis. This review provides an in-depth exploration of the role of the TRPV pathway in OA, encompassing its involvement in pain perception, inflammation, and mechanotransduction. Furthermore, we discuss the latest research findings, potential therapeutic strategies, and future directions in the field, shedding light on the multifaceted nature of TRPV channels in OA.

Keywords: TRPV channels; inflammation; mechanotransduction; osteoarthritis; therapeutic strategies.

Publication types

  • Review

MeSH terms

  • Humans
  • Inflammation
  • Mechanotransduction, Cellular
  • Osteoarthritis* / pathology
  • TRPV Cation Channels / genetics
  • TRPV Cation Channels / metabolism
  • Transient Receptor Potential Channels* / metabolism

Substances

  • Transient Receptor Potential Channels
  • TRPV Cation Channels