Acute myeloblastic leukemia and sarcoidosis. Implications for pathogenesis

Cancer. 1985 Jan 15;55(2):366-9. doi: 10.1002/1097-0142(19850115)55:2<366::aid-cncr2820550212>3.0.co;2-1.

Abstract

A disorder characterized by anemia and neutropenia due to impaired bone marrow function and a multisystem noncaseating granulomatous (NCG) disorder typical of sarcoidosis, culminated in acute myeloblastic leukemia (AML) in a patient after 6 years of observation. Linkage between the leukemia and sarcoidosis is suggested by a precedent case report, by the statistical remoteness of a fortuitous concurrence, by numerous reported instances of regional or systemic NCG accompanying a variety of malignancies, and by evidence of AML immunogenicity. It appears possible that the sarcoidosis in this patient represented a tissue reaction to the AML.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anemia / etiology
  • Biopsy
  • Bone Marrow / pathology
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / pathology
  • Liver / pathology
  • Liver Diseases / etiology*
  • Liver Diseases / pathology
  • Lung / pathology
  • Lung Diseases / etiology*
  • Lung Diseases / pathology
  • Neutropenia / etiology
  • Sarcoidosis / etiology*
  • Sarcoidosis / pathology