The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection

Isaura Rigo; Mary K Young; Mayuresh M Abhyankar; Feifan Xu; Girija Ramakrishnan; Farha Naz; Gregory R Madden; William A Petri

doi:10.1016/j.anaerobe.2024.102842

The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection

Anaerobe. 2024 Mar 28:87:102842. doi: 10.1016/j.anaerobe.2024.102842. Online ahead of print.

Authors

Isaura Rigo¹, Mary K Young¹, Mayuresh M Abhyankar¹, Feifan Xu¹, Girija Ramakrishnan¹, Farha Naz¹, Gregory R Madden¹, William A Petri²

Affiliations

¹ University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
² University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA. Electronic address: wap3g@virginia.edu.

PMID: 38552897
DOI: 10.1016/j.anaerobe.2024.102842

Abstract

Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.

Keywords: C. difficile infection (CDI); Neutralizing antibodies; anti-toxin B IgG antibodies.

Abstract

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