MICU1's calcium sensing beyond mitochondrial calcium uptake

Biochim Biophys Acta Mol Cell Res. 2024 Jun;1871(5):119714. doi: 10.1016/j.bbamcr.2024.119714. Epub 2024 Mar 29.

Abstract

The discovery of MICU1 as gatekeeper of mitochondrial calcium (mCa2+) entry has transformed our understanding of mCa2+ flux. Recent studies revealed an additional role of MICU1 as a Ca2+ sensor at MICOS (mitochondrial contact site and cristae organizing system). MICU1's presence at MICOS suggests its involvement in coordinating Ca2+ signaling and mitochondrial ultrastructure. Besides its role in Ca2+ regulation, MICU1 influences cellular signaling pathways including transcription, epigenetic regulation, metabolism, and cell death, thereby affecting human health. Here, we summarize recent findings on MICU1's canonical and noncanonical functions, and its relevance to human health and diseases.

Keywords: Calcium; MCU; MICOS; MICU1; Mitochondria.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Calcium Signaling*
  • Calcium* / metabolism
  • Calcium-Binding Proteins* / genetics
  • Calcium-Binding Proteins* / metabolism
  • Cation Transport Proteins / chemistry
  • Cation Transport Proteins / genetics
  • Cation Transport Proteins / metabolism
  • Humans
  • Mitochondria* / metabolism
  • Mitochondrial Membrane Transport Proteins* / genetics
  • Mitochondrial Membrane Transport Proteins* / metabolism

Substances

  • Calcium
  • Mitochondrial Membrane Transport Proteins
  • MICU1 protein, human
  • Calcium-Binding Proteins
  • Cation Transport Proteins