HLA and nasopharyngeal carcinoma in Malays

Br J Cancer. 1985 Mar;51(3):389-92. doi: 10.1038/bjc.1985.52.

Abstract

HLA associations were observed in unrelated Malay patients with nasopharyngeal carcinoma (NPC). HLA-B18 was observed in 18/45 (40%) Malay NPC patients compared to 22/167 (13%) Malay normals (P = 0.0001; Pc = 0.0027, RR = 4.4). The frequency of HLA-B17, one of the antigens associated with Chinese NPC, was also increased among Malay NPC (13/45 29%) compared to controls (18/167 11%; P = 0.003, Pc = 0.07 RR = 3.4). Similar to the findings among Chinese NPC, the frequency of B17 was higher in early onset (less than or equal to 30 years) Malay NPC resulting in a higher relative risk (RR = 5.0).

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Asian Continental Ancestry Group*
  • HLA Antigens / analysis*
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-B18 Antigen
  • Humans
  • Malaysia
  • Middle Aged
  • Nasopharyngeal Neoplasms / immunology*

Substances

  • HLA Antigens
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-B17 antigen
  • HLA-B18 Antigen