The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling

Haizhu Gao; Zhongxin Li; Lijun Gan; Xueying Chen

doi:10.1007/s12265-024-10498-7

The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling

J Cardiovasc Transl Res. 2024 Apr 1. doi: 10.1007/s12265-024-10498-7. Online ahead of print.

Authors

Haizhu Gao¹, Zhongxin Li¹, Lijun Gan², Xueying Chen^{3

4}

Affiliations

¹ Colleague of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
² Department of Cardiology, Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, No.89 Guhuai Road, Jining, 272029, Shandong, China.
³ Department of Cardiology, Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, No.89 Guhuai Road, Jining, 272029, Shandong, China. chenxueying0202@mail.jnmc.edu.cn.
⁴ Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China. chenxueying0202@mail.jnmc.edu.cn.

PMID: 38558377
DOI: 10.1007/s12265-024-10498-7

Abstract

Rehabilitation exercise is a crucial non-pharmacological intervention for the secondary prevention and treatment of cardiovascular diseases, effectively ameliorating cardiac remodeling in patients. Exercise training can mitigate cardiomyocyte apoptosis, reduce extracellular matrix deposition and fibrosis, promote angiogenesis, and regulate inflammatory response to improve cardiac remodeling. This article presents a comprehensive review of recent research progress, summarizing the pivotal role and underlying mechanism of rehabilitation exercise in improving cardiac remodeling and providing valuable insights for devising effective rehabilitation treatment programs. Graphical Abstract.

Keywords: Cardiac remodeling; Myocardial infarction; Pathogenic mechanism; Rehabilitation exercise.

Publication types

Review