Two-Week Interruption of Statin Therapy Results in an Exaggerated Inflammatory Monocyte Phenotype in Young Patients With Myocardial Infarction Without Standard Modifiable Risk Factors

J Am Heart Assoc. 2024 Apr 16;13(8):e032978. doi: 10.1161/JAHA.123.032978. Epub 2024 Apr 2.

Authors

Jan-Quinten Mol¹, Julia van Tuijl², Siroon Bekkering², Laura Rodwell³, Gheorghe A M Pop¹, Mihai G Netea^{2

4}, Niels van Royen¹, Niels P Riksen², Saloua El Messaoudi¹

Affiliations

¹ Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands.
² Department of Internal Medicine Radboud University Medical Center Nijmegen the Netherlands.
³ Section Biostatistics, Department for Health Evidence Radboud Institute for Health Sciences, Radboud University Medical Center Nijmegen the Netherlands.
⁴ Department of Immunology and Metabolism Life and Medical Sciences Institute, University of Bonn Bonn Germany.

No abstract available

Keywords: inflammation; monocytes; myocardial infarction; standard modifiable risk factors; statins.

MeSH terms

Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
Monocytes
Myocardial Infarction* / therapy
Phenotype
Risk Factors

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors