Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial
J Am Soc Nephrol
.
2024 Feb 20.
doi: 10.1681/ASN.0000000000000326.
Online ahead of print.
Authors
Hiddo J L Heerspink
1
2
,
Austin G Stack
3
,
Robert Terkeltaub
4
,
Niels Jongs
1
,
Lesley A Inker
5
,
Magnus Bjursell
6
,
Noha Maklad
7
,
Shira Perl
7
,
Olof Eklund
6
,
Tord Rikte
6
,
C David Sjöström
6
,
Vlado Perkovic
2
8
;
SAPPHIRE Investigators
Collaborators
SAPPHIRE Investigators
:
Hana Chmelickova
,
Martin Lukac
,
Petr Bucek
,
Tomas Drasnar
,
Bertrand Dussol
,
Dominique Guerrot
,
Eric Legrand
,
Jean-Jacques Boffa
,
Jean-Michel Halimi
,
Philippe Zaoui
,
Annamaria Letoha
,
Csaba Hajdu
,
Denes Pall
,
Eva Peterfai
,
Gyöngyi Csécsei
,
Katalin Bezzegh
,
Laszlo Deak
,
Laszlo Konyves
,
Marianna Zsom
,
Peter Danos
,
Sandor Vangel
,
Szilard Vasas
,
Tamas Oroszlan
,
Zsolt Zilahi
,
Adi Leiba
,
Alon Grossman
,
Avshalom Leibowitz
,
Baruch Itzhak
,
Deeb Daoud
,
Evgeny Farber
,
Faiad Adawi
,
Farid M Nakhoul
,
Gil Chernin
,
Irina Kenis
,
Julio Wainstein
,
Lior Zeller
,
Mazen Elias
,
Shaul Atar
,
Victor Frajewicki
,
Yoram Yagil
,
Zaher A Armaly
,
Ciro Esposito
,
Francesca Viazzi
,
Giovanni Gambaro
,
Piermarco Piatti
,
Riccardo C Bonadonna
,
Cristhian Ronaldt Arias Delgadillo
,
Fernando Jimenez Flores
,
Manuel Enrique Aguilera Real
,
Pedro Fajardo-Campos
,
Rafael Margarito Violante Ortiz
,
Rosa Isela Luna Ceballos
,
Sergio Duran-Barragan
,
Danuta Zytkiewicz-Jaruga
,
Ewa Krzyzagorska
,
Ewa Skokowska
,
Katarzyna Klodawska
,
Robert Mordaka
,
Stanislaw Mazur
,
Teresa Stasinska
,
Wladyslaw Sulowicz
,
Ciprian Constantin
,
Doru Negru
,
Fraga-Silvia Paveliu
,
Gabriela Doina Negrisanu
,
Iosif Szilagyi
,
Mihaela Magdalena G Busegeanu
,
Mihai Cosmin Pena
,
Rodica Ioana Avram
,
Silvia Luminita Ardelean
,
Adriana Ilavska
,
Andrej Dzupina
,
Aniko Oroszova
,
Eva Kolesarova
,
Ida Obetkova
,
Iveta Smatanova
,
Jana Babikova
,
Peter Fulop
,
Radovan Haffner
,
Brian L Rayner
,
Dawid Stephanus Kruger
,
Dorothea Vera Urbach
,
Essack Mitha
,
Gulam Hoosain Vally Mahomed Latiff
,
Hemant Makan
,
Hermanus du Plessis
,
Jaco Cornelius Jurgens
,
Jeevren Reddy
,
Julien S Trokis
,
Kirsten McHarry
,
Lawrence Allen Distiller
,
Leila Mayet
,
Lesley Jean Burgess
,
Louis Johan Van Zyl
,
Mukesh P Joshi
,
Peter John Sebastian
,
Samantha Maria Du Toit
,
Suzanne C Blignaut
,
Antonio Galan Serrano
,
Cristobal Morales
,
Esteban Poch
,
Eva Marquez Mosquera
,
Fernando Cereto Castro
,
Francisco Javier Gonzalez Martinez
,
Francisco Javier Perez-Contreras
,
Gema Fernandez-Fresnedo
,
Isabel Fuencisla Garcia Mendez
,
Jonay Pantoja Perez
,
Jordi Calabia Martinez
,
Jose Luis Gorriz Teruel
,
Luis Javier Nieto Iglesias
,
Manuel Munoz-Torres
,
Maria Antonia Munar Vila
,
Maria Dolores Arenas Jimenez
,
Marta E Dominguez-Lopez
,
Miguel Hueso Val
,
Natalia Ramos Terrades
,
Rafael Santamaria Olmo
,
Tamara Gelen Malek Marin
,
Ahmed A Arif
,
Benjamin J Lee
,
Bhasker R Mehta
,
Bruce H Baker
,
Charles S Jere
,
David G Bains
,
David G Stricklin
,
Deanna Cheung
,
Diego Echeverri
,
Edgard Vera
,
Eva-Maria Heurich
,
Gary A Sterba
,
German T Hernandez
,
Henry E Paez
,
Idalia A Acosta
,
Intekhab Ahmed
,
Issac Sachmechi
,
Ivy-Joan E Madu
,
Jagdeep Singh Obhrai
,
Jamal A Hammoud
,
James A Tumlin
,
James Cain
,
Jaynier Moya-Hechevarria
,
Jeffrey J Connaire
,
Jehad Haggiagi
,
Jennifer A Odren
,
Jennifer M Bellucci-Jackson
,
Jieshi Yan
,
John C Parker
,
Jonathan P Tolins
,
Jose D Gomez-Cortes
,
Jose F Cardona
,
Jose M Mandry
,
Juan Jorge Olivero
,
Kendra S Hendon
,
Kianoosh Kaveh
,
Laura A Kooienga
,
Lidia R Bermudez
,
Lisa M Rich
,
Marina Gold
,
Marisela Gonzalez
,
Matthew E Schaefer
,
Michelle Welch
,
Moustafa A Moustafa
,
Murtaza Mussaji
,
Pablo E Pergola
,
Piangwarin Phaosawasdi
,
Ricardo A Silva
,
Ricardo Presas
,
Robert I Lynn
,
Saeed J Kronfli
,
Sailaja V Ventrapragada
,
Sankar N Niranjan
,
Sayed Husain
,
Scott Satko
,
Serge A Jabbour
,
Sergio F Rovner
,
Steven F Gouge
,
Sudhir S Joshi
,
Varagur Bala Ramachandran Subramanian
,
Wendy Lane
,
Wesley Calhoun
,
William Durham
Affiliations
1
Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
2
The George Institute for Global Health, Sydney, Australia.
3
School of Medicine & Health Research Institute, University of Limerick, Limerick, Ireland.
4
University of California San Diego, La Jolla, California.
5
Division of Nephrology, Tufts Medical Center, Boston, Massachusetts.
6
Late-Stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca, Gothenburg, Sweden.
7
Late-Stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca, Gaithersburg, Maryland.
8
University New South Wales, Sydney, Australia.
PMID:
38564654
DOI:
10.1681/ASN.0000000000000326
No abstract available
Associated data
ClinicalTrials.gov/NCT03990363
ClinicalTrials.gov/NCT03036150
Grants and funding
AstraZeneca