Retinal Disorders

José-Alain Sahel; Eyal Banin; Jean Bennett; Jacque L Duncan; Botond Roska

doi:10.1101/cshperspect.a041728

Retinal Disorders

Cold Spring Harb Perspect Med. 2024 Apr 2:a041728. doi: 10.1101/cshperspect.a041728. Online ahead of print.

Authors

José-Alain Sahel¹, Eyal Banin², Jean Bennett³, Jacque L Duncan⁴, Botond Roska⁵

Affiliations

¹ The UPMC Vision Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA sahelja@upmc.edu jebennet@pennmedicine.upenn.edu botond.roska@iob.ch jacque.duncan@ucsf.edu banine@mail.huji.ac.il.
² Division of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel sahelja@upmc.edu jebennet@pennmedicine.upenn.edu botond.roska@iob.ch jacque.duncan@ucsf.edu banine@mail.huji.ac.il.
³ Center for Advanced Retinal and Ocular Therapeutics, 309C Stellar-Chance Labs, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA sahelja@upmc.edu jebennet@pennmedicine.upenn.edu botond.roska@iob.ch jacque.duncan@ucsf.edu banine@mail.huji.ac.il.
⁴ Department of Ophthalmology, University of California, San Francisco, California 94143, USA sahelja@upmc.edu jebennet@pennmedicine.upenn.edu botond.roska@iob.ch jacque.duncan@ucsf.edu banine@mail.huji.ac.il.
⁵ Institute of Molecular and Clinical Ophthalmology Basel, Basel 4031, Switzerland sahelja@upmc.edu jebennet@pennmedicine.upenn.edu botond.roska@iob.ch jacque.duncan@ucsf.edu banine@mail.huji.ac.il.

PMID: 38565268
DOI: 10.1101/cshperspect.a041728

Abstract

Retinal disorders caused by genetic or environmental factors cause severe visual impairment and often result in blindness. The past ten years have seen rapid progress in our understanding of the biological basis of these conditions, as well as significant advances towards gene and cell-based therapies. Regulatory challenges remain, but there is reason to hope that creative approaches will lead to safe and effective breakthrough treatments for these conditions in the near future.

Publication types

Editorial