Revolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy

Drug Des Devel Ther. 2024 Mar 29:18:991-1006. doi: 10.2147/DDDT.S460998. eCollection 2024.

Abstract

Stem cells, renowned for their unique regenerative capabilities, present significant hope in treating stroke, a major cause of disability globally. This review offers a detailed analysis of stem cell applications in stroke (ischemic and hemorrhagic) recovery. It examines therapies based on autologous (patient-derived), allogeneic (donor-derived), and Granulocyte-Colony Stimulating Factor (G-CSF) based stem cells, focusing on cell types such as Mesenchymal Stem/Stromal Cells (MSCs), Bone Marrow Mononuclear Stem Cells (BMMSCs), and Neural Stem/Progenitor Cells (NSCs). The paper compiles clinical trial data to evaluate their effectiveness and safety and addresses the ethical concerns of these innovative treatments. By explaining the mechanisms of stem cell-induced neurological repair, this review underscores stem cells' potential in revolutionizing stroke rehabilitation and suggests avenues for future research.

Keywords: allogeneic stem cells transplantation; autologous stem cells transplantation; brain hemorrhage; granulocyte-colony stimulating factor; stem cell therapy; stroke.

Publication types

  • Review

MeSH terms

  • Cell- and Tissue-Based Therapy
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Stem Cells
  • Stroke* / drug therapy
  • Transplantation, Autologous

Substances

  • Granulocyte Colony-Stimulating Factor