Rhythmicity of neuronal oscillations delineates their cortical and spectral architecture

Commun Biol. 2024 Apr 3;7(1):405. doi: 10.1038/s42003-024-06083-y.

Abstract

Neuronal oscillations are commonly analyzed with power spectral methods that quantify signal amplitude, but not rhythmicity or 'oscillatoriness' per se. Here we introduce a new approach, the phase-autocorrelation function (pACF), for the direct quantification of rhythmicity. We applied pACF to human intracerebral stereoelectroencephalography (SEEG) and magnetoencephalography (MEG) data and uncovered a spectrally and anatomically fine-grained cortical architecture in the rhythmicity of single- and multi-frequency neuronal oscillations. Evidencing the functional significance of rhythmicity, we found it to be a prerequisite for long-range synchronization in resting-state networks and to be dynamically modulated during event-related processing. We also extended the pACF approach to measure 'burstiness' of oscillatory processes and characterized regions with stable and bursty oscillations. These findings show that rhythmicity is double-dissociable from amplitude and constitutes a functionally relevant and dynamic characteristic of neuronal oscillations.

MeSH terms

  • Attention / physiology
  • Humans
  • Magnetoencephalography* / methods
  • Neurons / physiology
  • Periodicity*
  • Stereotaxic Techniques