Three new pterosins from Pteris semipinnata

Nat Prod Res. 2024 May;38(9):1591-1598. doi: 10.1080/14786419.2022.2162895. Epub 2023 Jan 12.


Three new pterosins, named as semipterosin A (1), B (2) and C (3), together with 11 known pterosins (4-14), were isolated from the aerial parts of Pteris semipinnata. Their structures were elucidated by HRESI-MS, NMR spectral data, CD and literature comparisons. Three new pterosins were assessed for their anti-inflammatory activity. Compounds 1-3 inhibited the NF-kB induction by 40.7%, 61.9% and 34.0%, respectively. This is the first report of the isolation of compounds 6-14 from this plant.

Keywords: Pteridaceae; Pteris semipinnata; anti-inflammatory; pterosin.

MeSH terms

  • Indans
  • NF-kappa B
  • Pteris*
  • Sesquiterpenes*


  • pterosin
  • Indans
  • NF-kappa B
  • Sesquiterpenes