Lymphangitic Melanomatosis: Case Report of Intralymphatic Spread of Melanoma in a 66-year-old Man

Am J Dermatopathol. 2024 May 1;46(5):316-319. doi: 10.1097/DAD.0000000000002696.


Melanoma with lymphatic invasion has been associated with increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread of melanoma and suggest lymphatic spread of melanoma to increase the likelihood of metastasis, to our knowledge, lymphangitic metastatic melanoma resembling cutaneous carcinomatosis or presenting with facial hyperpigmentation has not been described. In this case report, we describe extensive cutaneous intralymphatic spread of melanoma, or lymphangitic melanomatosis, producing macular skin pigmentation in a 66-year-old man.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell* / secondary
  • Humans
  • Lymphangitis* / complications
  • Male
  • Melanoma* / pathology