Characteristics and efficacy of traditional Chinese medicine in the therapeutic strategy of chronic coronary syndrome: A systematic review and meta-analysis

Xiao-Hui Ma; Yang Chen; Xiao-Yao Huang; Jia-Rong Jiang; Xin Liu; Dong-Qing An; Rong-Rong He

doi:10.1016/j.phymed.2024.155579

Characteristics and efficacy of traditional Chinese medicine in the therapeutic strategy of chronic coronary syndrome: A systematic review and meta-analysis

Phytomedicine. 2024 Mar 30:129:155579. doi: 10.1016/j.phymed.2024.155579. Online ahead of print.

Authors

Xiao-Hui Ma¹, Yang Chen², Xiao-Yao Huang², Jia-Rong Jiang², Xin Liu², Dong-Qing An³, Rong-Rong He⁴

Affiliations

¹ Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830054, China; National Traditional Chinese Medicine Inheritance and Innovation Center, Xinjiang Medical University, Urumqi 830054, China; Key Laboratory of High Incidence Diseases in Xinjiang Region, Ministry of Education (MOE), Xinjiang Medical University, Urumqi 830054, China; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Jinan University, Guangzhou 510632, China. Electronic address: xhma2@xjmu.edu.cn.
² Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830054, China; National Traditional Chinese Medicine Inheritance and Innovation Center, Xinjiang Medical University, Urumqi 830054, China; Key Laboratory of High Incidence Diseases in Xinjiang Region, Ministry of Education (MOE), Xinjiang Medical University, Urumqi 830054, China.
³ Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830054, China; National Traditional Chinese Medicine Inheritance and Innovation Center, Xinjiang Medical University, Urumqi 830054, China. Electronic address: 326468701@qq.com.
⁴ Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Jinan University, Guangzhou 510632, China. Electronic address: rongronghe@jnu.edu.cn.

PMID: 38574427
DOI: 10.1016/j.phymed.2024.155579

Abstract

Background and aims: Chronic coronary syndrome (CCS) has always been controversial in its therapeutic strategy. Although invasive treatment and optimal medication therapy (OMT) are the most commonly used treatments, doctors continue to debate the best strategy. However, traditional Chinese medicine (TCM) for CCS is effective clinically.

Methods: To identify potentially eligible observational and experimental studies, we searched Pubmed, the Web of Science, and the China National Knowledge Internet. To be eligible, studies had to report with end-of treatment outcomes, such as major adverse cardiac events (MACE), deaths from myocardial infarctions (MI), all-cause mortality, angina, cardiac mortality, the effectiveness rate of electrocardiographs, and the reduction rate of the Nitroglycerin tablets. Risk differences (RDs) and 95 % confidence intervals (95 % CIs) were calculated based on random-effects models or fixed-effects models. Citation screening, data abstraction, risk assessment, and strength-of-evidence grading were completed by 2 independent reviewers.

Results: In Section 1 (13 studies, involving 17,287 patients), showed no significant difference between invasive treatment and medication treatment in MACE (RD = -0.04, 95% CI = -0.08 to 0.00, I2 = 76.4 %), all-cause mortality (RD = -0.01, 95%CI = -0.022 to 0.01, I2 = 73.44 %), MI (RD = 0.00, 95%CI = -0.00 to 0.01, I2 = 0.00 %) and cardiac mortality (RD = 0.00, 95 %CI = -0.01 to 0.01, I2 = 34.9 %). In Section 2 (21 studies, including 1820 patients), compared with WM treatment, TCM + WM treatment increased ECG effectiveness by 18 %, angina effectiveness by 20 %, and stopping or reducing Nitroglycerin tablets by 20 %. In Section 3 (25 studies, including 2859 patients) showed that TCM revealed a better electrocardiogram effective rate (RD = 0.10, 95 %CI = 0.05 to 0.14, I2 = 44.7 %) and angina effective rate (RD = 0.12, 95 %CI = 0.09 to 0.15, I2 = 44.9 %). We identified that TCM treatment properties of "Circulating blood and transforming stasis" and application of warm/heat-properties medicines were frequently used in CCS treatment.

Conclusions: TCM treatment has shown superior beneficial cardioprotective in CCS therapy strategy, among which "Circulating blood and transforming stasis" and the application of warm/heat-properties medicine are its characteristics.

Keywords: Chronic coronary syndrome; Circulating blood and transforming stasis; Optimal medication therapy; Traditional Chinese Medicine; Warm/heat-properties medicine.

Publication types

Review