A nationwide phase II study of delayed local treatment for children with high-risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN-H-11

Pediatr Blood Cancer. 2024 Jun;71(6):e30976. doi: 10.1002/pbc.30976. Epub 2024 Apr 5.

Abstract

Purpose: Survival rates of patients with high-risk neuroblastoma are unacceptable. A time-intensified treatment strategy with delayed local treatment to control systemic diseases has been developed in Japan. We conducted a nationwide, prospective, single-arm clinical trial with delayed local treatment. This study evaluated the safety and efficacy of delayed surgery to increase treatment intensity.

Patients and methods: Seventy-five patients with high-risk neuroblastoma were enrolled in this study between May 2011 and September 2015. Delayed local treatment consisted of five courses of induction chemotherapy (cisplatin, pirarubicin, vincristine, and cyclophosphamide) and myeloablative high-dose chemotherapy (melphalan, etoposide, and carboplatin), followed by local tumor extirpation with surgery and irradiation. The primary endpoint was progression-free survival (PFS). The secondary endpoints were overall survival (OS), response rate, adverse events, and surgical complications.

Results: Seventy-five patients were enrolled, and 64 were evaluable (stage 3, n = 8; stage 4, n = 56). The estimated 3-year PFS and OS rates (95% confidence interval [CI]) were 44.4% [31.8%-56.3%] and 80.7% [68.5%-88.5%], resspectively. The response rate of INRC after completion of the treatment protocol was 66% (42/64; 95% CI: 53%-77%; 23 CR [complete response], 10 VGPR [very good partial response], and nine PR [partial response]). None of the patients died during the protocol treatment or within 30 days of completion. Grade 4 adverse effects, excluding hematological adverse effects, occurred in 48% of patients [31/64; 95% CI: 36%-61%]. Major Surgical complications were observed in 25% of patients [13/51; 95% CI: 14%-40%].

Conclusion: This study indicates that delayed local treatment is feasible and shows promising efficacy, suggesting that this treatment should be considered further in a comparative study of high-risk neuroblastoma.

Keywords: clinical trial; delayed local treatment; high risk; multidisciplinary treatment; neuroblastoma.

Publication types

  • Clinical Trial, Phase II
  • Research Support, Non-U.S. Gov't
  • Multicenter Study

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols* / therapeutic use
  • Child
  • Child, Preschool
  • Cisplatin / administration & dosage
  • Cisplatin / therapeutic use
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / administration & dosage
  • Doxorubicin / analogs & derivatives*
  • Doxorubicin / therapeutic use
  • Etoposide / administration & dosage
  • Female
  • Follow-Up Studies
  • Humans
  • Induction Chemotherapy
  • Infant
  • Japan / epidemiology
  • Male
  • Melphalan / administration & dosage
  • Melphalan / therapeutic use
  • Neuroblastoma* / drug therapy
  • Neuroblastoma* / mortality
  • Neuroblastoma* / pathology
  • Neuroblastoma* / therapy
  • Prognosis
  • Prospective Studies
  • Survival Rate
  • Vincristine / administration & dosage
  • Vincristine / therapeutic use

Substances

  • Etoposide
  • Vincristine
  • Cyclophosphamide
  • Doxorubicin
  • pirarubicin
  • Melphalan
  • Cisplatin