Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis

Tannaz Jamialahamdi; Ali H Eid; Ninh T Nguyen; Kishore M Gadde; Vasily N Sukhorukov; Wael Almahmeed; Matthew Kroh; Amirhossein Sahebkar

doi:10.1007/s11695-024-07210-8

Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis

Obes Surg. 2024 May;34(5):1929-1937. doi: 10.1007/s11695-024-07210-8. Epub 2024 Apr 5.

Authors

Tannaz Jamialahamdi^#^{1

2}, Ali H Eid^#³, Ninh T Nguyen⁴, Kishore M Gadde⁴, Vasily N Sukhorukov^{5

6}, Wael Almahmeed⁷, Matthew Kroh⁸, Amirhossein Sahebkar^{9

10

11}

Affiliations

¹ Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
² Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
⁴ Department of Surgery, University of California Irvine Medical Center, Orange, CA, USA.
⁵ Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, 125315, Russia.
⁶ Petrovsky National Research Centre of Surgery, Moscow, Russia.
⁷ Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
⁸ Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
⁹ Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. amir_saheb2000@yahoo.com.
¹⁰ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
¹¹ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

^# Contributed equally.

PMID: 38578522
DOI: 10.1007/s11695-024-07210-8

Abstract

CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), - 0.531; 95% CI, - 0.981, - 0.082; p = 0.021; I², 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.

Keywords: CD40L; Immune system; Inflammation; Metabolic bariatric surgery; Weight loss.

Publication types

Meta-Analysis
Systematic Review
Review

MeSH terms

Bariatric Surgery*
CD40 Ligand
Cardiovascular Diseases*
Heart Disease Risk Factors
Humans
Obesity, Morbid* / surgery
Risk Factors

Substances

CD40 Ligand