Current status and progress of research on the ADP-dependent glucokinase gene

Ningjing Guo; Qiong Luo; Qixian Zheng; Sheng Yang; Suyun Zhang

doi:10.3389/fonc.2024.1358904

Current status and progress of research on the ADP-dependent glucokinase gene

Front Oncol. 2024 Mar 25:14:1358904. doi: 10.3389/fonc.2024.1358904. eCollection 2024.

Authors

Ningjing Guo¹, Qiong Luo¹, Qixian Zheng², Sheng Yang¹, Suyun Zhang³

Affiliations

¹ Department of Oncology Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
² Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
³ Department of Internal Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Abstract

ADP-dependent glucokinase (ADPGK) produces glucose-6-phosphate with adenosine diphosphate (ADP) as the phosphate group donor, in contrast to ATP-dependent hexokinases (HKs). Originally found in archaea, ADPGK is involved in glycolysis. However, its biological function in most eukaryotic organisms is still unclear, and the molecular mechanism of action requires further investigation. This paper provides a concise overview of ADPGK's origin, biological function and clinical application. It aims to furnish scientific information for the diagnosis and treatment of human metabolic diseases, neurological disorders, and malignant tumours, and to suggest new strategies for the development of targeted drugs.

Keywords: ADP-dependent glucokinase; glycolysis; immunotherapy; malignant tumours; targeted therapy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Joint Funds for the innovation of science and Technology, Fujian province under Grant number 2021Y9066.