Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

Am J Hum Genet. 1985 May;37(3):482-98.


Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. We consider the appropriateness of assuming no interference with data available in human genetic studies. Examples are given to show the significance of multilocus analysis in humans. A computer program package, LINKAGE, for multilocus linkage analysis is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping*
  • Genes
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Models, Genetic*
  • Pedigree
  • Probability
  • Recombination, Genetic*


  • Genetic Markers