The Utility of Prostate-Specific Membrane Antigen-11 PET in Detection and Management of Central Nervous System Neoplasms

Clin Nucl Med. 2024 Jul 1;49(7):e340-e345. doi: 10.1097/RLU.0000000000005157. Epub 2024 Apr 5.

Abstract

We present a case series of 5 patients diagnosed with schwannoma and 1 patient diagnosed with astrocytoma who underwent PSMA PET imaging for tumor detection. We retrospectively analyzed the records of 4 male and 2 female patients (mean age, 53.2 ± 13.2) who underwent PSMA PET imaging between March and September 2023. PET interpretation showed increased Ga-PSMA-11 accumulation in all patients with a mean SUV max of 3.11 ± 1.8. This series underscores PSMA PET's potential for CNS neoplasm detection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antigens, Surface / metabolism
  • Central Nervous System Neoplasms* / diagnostic imaging
  • Edetic Acid / analogs & derivatives
  • Female
  • Gallium Isotopes*
  • Gallium Radioisotopes
  • Glutamate Carboxypeptidase II / metabolism
  • Humans
  • Male
  • Middle Aged
  • Oligopeptides
  • Positron-Emission Tomography*
  • Retrospective Studies

Substances

  • Gallium Isotopes
  • gallium 68 PSMA-11
  • Glutamate Carboxypeptidase II
  • FOLH1 protein, human
  • Gallium Radioisotopes
  • Edetic Acid
  • Oligopeptides
  • Antigens, Surface