Progress of engineered bacteria for tumour therapy

Int Immunopharmacol. 2024 May 10:132:111935. doi: 10.1016/j.intimp.2024.111935. Epub 2024 Apr 9.


Finding novel therapeutic modalities, improving drug delivery efficiency and targeting, and reducing the immune escape of tumor cells are currently hot topics in the field of tumor therapy. Bacterial therapeutics have proven highly effective in preventing tumor spread and recurrence, used alone or in combination with traditional therapies. In recent years, a growing number of researchers have significantly improved the targeting and penetration of bacteria by using genetic engineering technology, which has received widespread attention in the field of tumor therapy. In this paper, we provide an overview and assessment of the advancements made in the field of tumor therapy using genetically engineered bacteria. We cover three major aspects: the development of engineered bacteria, their integration with other therapeutic techniques, and the current state of clinical trials. Lastly, we discuss the limitations and challenges that are currently being faced in the utilization of engineered bacteria for tumor therapy.

Keywords: Bacteria; Genetically engineered bacteria; Targeted therapy; Tumor.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria* / genetics
  • Drug Delivery Systems
  • Genetic Engineering*
  • Humans
  • Immunotherapy / methods
  • Neoplasms* / immunology
  • Neoplasms* / therapy