Primary hepatic pleomorphic liposarcoma: Case report and literature review

Rev Esp Patol. 2024 Apr-Jun;57(2):128-132. doi: 10.1016/j.patol.2023.10.003. Epub 2023 Dec 7.

Abstract

Primary hepatic liposarcoma is an extremely rare malignant tumour derived from adipocytes and is part of the group of mesenchymal tumours. We present the case of a 43-year-old Hispanic male patient with a pleomorphic hepatic liposarcoma and absence of MDM2 gene amplification. Two years and six months after surgery, the patient is asymptomatic. The present case is the first report of this entity with positive immunohistochemical testing for p16, p53, S100, vimentin and absence of MDM2 gene amplification.

Keywords: Case report; Liposarcoma; Liposarcoma hepático pleomorfo; MDM2; Pleomorphic hepatic liposarcoma; Presentación de un caso clínico; p16; p53.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adipocytes / pathology
  • Adult
  • Humans
  • Liposarcoma* / pathology
  • Male
  • Proto-Oncogene Proteins c-mdm2* / genetics

Substances

  • Proto-Oncogene Proteins c-mdm2