Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression

Can J Neurol Sci. 1985 May;12(2):106-10. doi: 10.1017/s0317167100046795.


We have examined the distribution of HLA antigens in 70 multiple sclerosis (MS) patients divided in three groups defined according to clinical criteria: benign MS, severe MS, cerebellar MS. We have found a significant association between severe MS and HLA-DR2, and between benign MS of more than 15 years of evolution and HLA-DR3. We review previous work along the same line and conclude that the association of HLA antigens with "clinical subgroups of MS" could indicate a genetically based heterogeneity of the disease and offer help in establishing a prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cerebellar Diseases / genetics
  • Genetic Markers
  • HLA Antigens / analysis*
  • Histocompatibility Antigens Class II / analysis*
  • Humans
  • Multiple Sclerosis / genetics*
  • Prognosis


  • Genetic Markers
  • HLA Antigens
  • Histocompatibility Antigens Class II